SLIPS inspires second generation

first_imgMost any medical device implanted in the body — or one that comes into contact with flowing blood, such as a dialysis machine — may also present two critical challenges for the patient: blood clotting and bacterial infection.In a study reported in Nature Biotechnology, a team of Harvard scientists and engineers has developed a new surface coating for medical devices using materials already approved by the Food and Drug Administration (FDA). The researchers noted that the coating repelled blood from more than 20 medically relevant substrates (glass, plastic, and metal) and also suppressed biofilm formation.The team also implanted medical-grade tubing and catheters coated with the material in large blood vessels in pigs. The coating prevented blood from clotting for at least eight hours without the use of blood thinners like heparin, which can cause side effects, such as excessive bleeding.“Devising a way to prevent blood clotting without using anticoagulants is one of the holy grails in medicine,” said Don Ingber, director of Harvard’s Wyss Institute for Biologically Inspired Engineering and senior author of the study. Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital, as well as professor of bioengineering at Harvard’s School of Engineering and Applied Sciences (SEAS).The idea for the coating evolved from SLIPS (slippery-liquid-infused porous surfaces), a pioneering surface technology developed by co-author Joanna Aizenberg, who is a Wyss Institute core faculty member and the Amy Smith Berylson Professor of Materials Science at SEAS.These glass slides were dipped in blood to demonstrate the effectiveness of the TLP coating. Blood does not adhere to the TLP-treated slide on the right.SLIPS was inspired by the slippery surface of the carnivorous pitcher plant. It repels nearly any material it contacts, and the liquid layer on its surface provides a barrier against everything from ice to crude oil and blood.“Traditional SLIPS uses porous, textured surface substrates to immobilize the liquid layer, whereas medical surfaces are mostly flat and smooth — so we further adapted our approach by capitalizing on the natural roughness of chemically modified surfaces of medical devices,” said Aizenberg, who leads the Wyss Institute’s adaptive materials group. “This is yet another incarnation of the highly customizable SLIPS platform that can be designed to create slippery, nonadhesive surfaces on any material.”In a two-step surface-coating process, the Wyss team chemically attached a monolayer of perfluorocarbon, which is similar to Teflon, then added a layer of liquid perfluorocarbon. The team calls the tethered perfluorocarbon plus the liquid layer a “tethered-liquid perfluorocarbon” surface, or TLP.The TLP coating achieved the following results:TLP-treated medical tubing stored for more than a year under normal temperature and humidity conditions still prevented clot formation.The TLP surface remained stable under the full range of clinically relevant physiological shear stresses, or rates of blood flow seen in catheters and central lines, all the way up to dialysis machines.The TLP coating repelled the components of blood that cause clotting (fibrin and platelets).When bacteria called Pseudomonas aeruginosa were grown in TLP-coated medical tubing for more than six weeks, less than one in a billion bacteria were able to adhere.The researchers even tested a TLP-coated surface with a gecko — the superstar of sticking whose footpads contain thousands of hairlike structures with tremendous adhesive strength. The gecko was unable to hold on.“We were wonderfully surprised by how well the TLP coating worked, particularly in vivo without heparin,” said one of the co-lead authors, Anna Waterhouse, a Wyss Institute postdoctoral fellow. “Usually the blood will start to clot within an hour in the extracorporeal circuit, so our experiments really demonstrate the clinical relevance of this new coating.”The project was funded by the Defense Advanced Research Projects Agency (DARPA) and the Wyss Institute.last_img read more

Sri Lanka beaten in Dilshan’s last game

first_imgTILLAKARATNE Dilshan’s illustrious international career ended on a losing note as Australia beat Sri Lanka by four wickets in Colombo, despite a dramatic late collapse, to complete a 2-0 series victory.In his 497th and final appearance for his country, the flamboyant Dilshan was only able to contribute a solitary run and the hosts were duly restricted to 128-9, with only Dhananjaya de Silva (62) and Kusal Perera (22) reaching double figures.Adam Zampa (3-16), James Faulkner (3-19) and John Hastings (2-23) impressed for Australia, who looked set to romp to victory when Glenn Maxwell (66 off 29 balls) dominated an opening stand of 93 with David Warner.However, Maxwell’s departure triggered an unexpected collapse on a pitch offering plentiful turn and Dilshan delighted the crowd by claiming 2-8 – including a wicket with what proved his final delivery – before a maximum from Travis Head eventually got the tourists home with 13 balls unused.Australia will therefore head home having won both limited-overs rubbers following their humbling 3-0 Test series defeat.While his final appearance did not go to plan prior to his late success with the ball, Dilshan was understandably lauded by Sri Lanka’s fans before, during and after yesterday’s match.One of only 11 players to have scored hundreds in all three formats, he boasts 17 671 international runs and is also his nation’s record run-scorer in T20s.ICC chief executive David Richardson hailed Dilshan’s contribution to Sri Lankan cricket.In a statement, Richardson said of the 39-year-old: “He will be remembered for his innovative strokes and as a destructive opener. He was also a useful spin bowler and an outstanding fielder. We congratulate Dilshan for a fine career and wish him every success in the future.”Sri Lanka were unable to generate any momentum with the bat yesterday following Dilshan’s early dismissal, which saw the veteran edge to first slip, chasing a wide ball from Hastings.All-rounder Faulkner and leg-spinner Zampa took centre stage thereafter as wickets fell at regular intervals, although De Silva’s maiden T20 international half-century at least ensured the hosts made it into three figures.A target of 129 never appeared likely to challenge an Australia side that posted a world record total of 263-3 in Tuesday’s first T20.Maxwell thumped 145 from 65 deliveries in that match and carried on where he left off, striking the joint-fastest T20 fifty by an Australian, from just 18 balls.Maxwell eventually played on to Seekkuge Prasanna (1-16), triggering a late flurry of wickets that threatened to turn the match on its head, but Australia were not to be denied.(Omnisport)last_img read more

Front foot no-ball technology to be used in women’s T20 World Cup – ICC

first_img(REUTERS) – Front foot no-ball technology will be used at a major tournament for the first time in this month’s women’s T20 World Cup in Australia, the International Cricket Council (ICC) said.The television umpire will monitor the landing foot of the bowlers after every ball and communicate to the on-field umpires whether it was a legal delivery.It is currently the responsibility of the on-field umpires to call no-balls when a bowler oversteps the mark.The decision follows successful trials conducted across 12 games in both India and West Indies, which saw 4 717 balls bowled and 13 no-balls called. The ICC said all deliveries were judged accurately.“Cricket has an excellent track record of introducing technology to support the decision-making of our match officials and I’m confident this technology will reduce the small number of front foot no-ball errors at the Women’s T20 World Cup,” ICC General Manager Geoff Allardice said in a statement here.“No-balls are difficult for umpires to call accurately, and even though the percentage of deliveries that are no-balls is low, it is important to call them correctly.“Since we first trialled this concept in the ODI (one-day international) series between England and Pakistan in 2016 the technology has improved significantly, enabling us to introduce it cost-effectively, and with minimum impact on the flow of the game.”The women’s T20 World Cup runs from February 21 to March 8.last_img read more

Women win, men struggle in golf events

first_imgUSC’s women’s golf team outplayed the competition and took home first place at the Windy City Collegiate Championship yesterday. The team, which was coming off of a sixth-place finish at the ANNIKA Intercollegiate, had a combined final score of 12-over 876 (294-287-295). Northwestern, Iowa State, Arizona and Oklahoma State rounded out the top five, respectively.Amazing Annie · Junior golfer Annie Park came out on top at the Windy City Collegiate Championship yesterday with a 5-under 211. – Photo courtesy of USC Sports InformationThe Woman of Troy enjoyed a successful first day of competition at the Windy City Collegiate Championship. The team was led by junior Annie Park, who returned to the team this week,  after qualifying for the final round of the LPGA “Q” school. The team had a six-stroke lead after the first day with a score of 5-over 581 (294-287). Northwestern and Oklahoma State rounded out the top three teams. Park finished the day at 2-under 142 (73-69) which put her in fourth place in her first competitive day of the year.Senior Doris Chen tied for sixth and sophomore Karen Chung tied for ninth. Chen had five birdies in the first two rounds while Chung had five birdies in the second round, enough to help her recover from her first 18 holes. Other results from the first two rounds included sophomore Gabriella Then tying for 26th, sophomore transfer Elizabeth Doty tying for 37th and junior Victoria Morgan tying for 66th.On Tuesday, Park led her team and finished atop the individual leaderboard with a final score of 5-under 211 (73-69-69).“It was really fun to be back around the team after being gone for the previous tournament,” Park said. “Collectively, we had a good plan to attack this really difficult golf course and I’m very pleased with the way we played both days.”Chen had another successful outing on Tuesday as well, finishing in a tie for fourth with an even score of 216 (71-73-72). Sophomore Karen Chung struggled after an impressive first day and fell to a tie for 19th in the individual rankings with a score of 6-over 222 (75-70-77). Junior Victoria Morgan made a jump in the rankings and finished in a tie for 54th with a score of 26-over 232 (78-80-74). Other results from the tournament included Then tying for 37th at 12-over 228 (75-70-77) and sophomore transfer Elizabeth Doty tying for 41st at 13-over 229 (75-77-77).“Thankfully we were able to pull out the win,” said women’s head coach Andrea Gaston. “Annie [Park] had a really strong back 9 that helped lead the team to the title, and Doris [Chen] hung in there with a top 4 finish. The Windy City lived up to its name.”The men’s team struggled on the first day of competition at the Nike Golf Collegiate. The team finished the first day in seventh place with a 22-over 582 (293-289) putting them 14 strokes behind first place Oregon. Washington and Texas were second and third after the first day. Freshman Sean Crocker tied for seventh with a combined score of 1-over 141 (73-68), which led his team after the first day of competition.Sophomore Rico Hoey overcame his six bogeys with four birdies to finish the day in a tie for 10th at 3-over 143 (72-71). Other results from the first day included senior Eric Sugimoto tied for 28th at 8-over 148 (74-74) and both junior Bobby Gojuangco and freshman Jonah Teixeira tied for 43rd at 11-over 151.The Trojans improved from their first day of competition by moving up a placement and finishing in sixth place in the inaugural Nike Golf Collegiate. The team finished with a combined score of 32-over 872 (293-289-290). Oregon finished in first place with a final score of 11-over 851. Stanford, Oklahoma, Washington and Texas rounded out the top five.Crocker climbed the player leaderboard on Tuesday and finished in fourth place with a final score of 2-under 208 (73-68-67).“We were extremely fortunate to play a famous PGA Tour course this week, Colonial Country Club. It was a true test and we had one player in particular meet the challenge in freshman Sean Crocker,” said men’s head coach Chris Zambri. “He played beautifully all three rounds.”Hoey had a rough final day of the tournament and dropped 12 spots in the standings and finished with a 10-over 220. Sugimoto finished in a tie for 29th with a final score of 12-over 222. Other results from the day included Gojuangco by finishing in a tie for 43rd at 15-over 225 and Texeira finished in a tie for 46th at 16-over 226.The Women of Troy will head up to Palo Alto, California, for the Stanford Intercollegiate from Oct. 17-19. Next up for the men’s team is the Bill Cullum Invitational in Simi Valley, California, from Oct. 20-21.last_img read more

James, Greinke keep Nats off balance, escape trouble for win

first_img Written By Josh James sailed a changeup high and tight to Ryan Zimmerman, going to a full count with two on and the Houston Astros clinging to a two-run, fifth-inning lead.Catcher Robinson Chirinos called for another change. James shook him off.Chirinos put down the same signal.“It was one of those situations where I trusted him,” James said. “He knew what to call and I just threw it.”James’ second changeup spun off the inside corner and would have been ball four, but Zimmerman swung over it. The Nationals wasted an opportunity yet again as the Astros won 4-1 Friday night and clawed back to 2-1 in the World Series after losing the first two games at home.Astros pitchers baffled batters when it mattered most, shutting down an October offense of uncanny timeliness.Washington had a .314 average with runners in scoring position in its first 12 postseason games, 68 points higher than any of the other nine postseason teams. The Nationals threatened in each of the first six innings Friday but went 0 for 10 with runners in scoring position and stranded 12. On a night of pitching dangerously, Zack Greinke and the Astros’ bullpen kept escaping.“A lot more runs could have been scored there,” Zimmerman said. “Had a chance a couple times but, yeah, that’s baseball.”Houston pitchers had just one 1-2-3 inning, by Will Harris in the seventh, just the fourth time the Astros retired the side in order in the Series.Unsustainable in the long run, but on this night good enough.Chirinos, who also homered Friday, spent six hours watching video before Game 1 at Minute Maid Park, examining Nationals’ plate appearances all the way back to 2017.“Just trying to look for anything I can take advantage in,” he said.He spent two-to-three hours at Nationals Park on Friday reviewing the first two games.“How they’re taking spins, how they’re swinging at fastballs, where they’re putting better swings,” he said. “We’re in the World Series. You have to put the time, the effort in this situation.”James relieved Greinke after Asdrúbal Cabrera’s two-out double put runners on second third. James’ 0-2 pitch sent Zimmerman sprawling, a 98 mph fastball near the batter’s head.“I think it scared me more than anything, but that’s part of the game,” said Zimmerman, who was slow to get up.Zimmerman took two balls, fouled off two, and took the first changeup. Then came the key moment.“I know Zimmerman chases the changeup,” Chirinos said. “JJ wanted to throw the slider. I didn’t think it was the right pitch in that situation. Something I saw.”James wasn’t hard to persuade.“I knew if I got it relatively in the zone, around the zone, I could get him to swing, hopefully some soft contact or get him to swing and miss,” he explained.James, who got the win, combined with Brad Peacock, Will Harris, Joe Smith and Roberto Osuna for 4 1/3 innings of shutout, two-hit relief.Greinke, pitching four days after his 36th birthday, was 0-2 with a 6.43 ERA in his first three starts. He displayed his broad repertoire against the Nationals, mixing four-seam fastballs (39) and two-seamers (six) with curveballs (18), changeups (18) and sliders (14) to keep batters off-balance.“We were kind of surprised early that they were swinging at Zack’s curveball,” said Chirinos, who was so alarmed at Washington’s approach that Houston checked video to make sure Greinke wasn’t tipping the curves.Greinke’s fastest pitch was 93 mph, and his slowest 67. He struck out Juan Soto, playing on his 21st birthday, on a 72 mph curve to strand a runner at second in the first inning, fanned Cabrera on a curve with two on to end the third and retired Trea Turner with a curve hit for a grounder to leave a runner at third base in the fourth.With two on in the second, Victor Robles grounded a fastball for a 5-4-3 double play.“He toys with the strike zone. He never really concedes,” Astros manager AJ Hinch said. “He would rather pitch carefully to you than necessarily throw a ball right down the middle.”Greinke fell one out short of getting the win but was more concerned about taxing his bullpen ahead of Houston’s all-reliever pitching plan for Game 4 Saturday.“We might have used a guy a little more, to make it a little harder for tomorrow,” he said.Osuna, booed loudly when he entered, froze Soto with a 99 mph fastball for a called third strike to end it. The Astros lined up in front of the third-base dugout for handshakes.“It brings a lot of confidence back,” he said.Houston managed to avoid a sweep. And maybe more.___More AP MLB: and WATCH US LIVE SUBSCRIBE TO US LIVE TV FOLLOW UScenter_img Associated Press Television News Last Updated: 26th October, 2019 23:17 IST James, Greinke Keep Nats Off Balance, Escape Trouble For Win Josh James sailed a changeup high and tight to Ryan Zimmerman, going to a full count with two on and the Houston Astros clinging to a two-run, fifth-inning lead. COMMENT First Published: 26th October, 2019 23:17 ISTlast_img read more