Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A 52-year-old Freeport man was crushed to death under nearly a ton of rock while working at a stone distribution company in Farmingdale on Wednesday.Suffolk County police said Hector Vicenty was working at European Granite and Marble Group on Dubon Court, when he was crushed by two 800 pound slabs of quartzite at 2:12 p.m.The victim was taken to St. Joseph Hospital in Bethpage, where he was pronounced dead.Homicide Squad detectives are continuing the investigation.The Occupational Safety and Health Administration (OSHA) was notified and responded to the scene.The Nassau County Medical Examiner’s Office will perform an autopsy to determine the victim’s cause of death.
By Nick MulvenneySYDNEY, Australia (Reuters) – Any hopes New Zealand had that the New Year would bring a change of fortune on their tour of Australia were shattered yesterday by a combination of illness, a lost toss, some questionable selections and brilliant batting from their hosts.At the end of the first day of the third Test, a match the Black Caps must at least draw to avoid a 3-0 series sweep, they were already in a big hole with Australia on 283 for three and centurion Marnus Labuschagne still at the crease.The first blow did not come entirely out of the blue with captain Kane Williamson and batsman Henry Nicholls having missed training on the previous two days with a flu bug that was sweeping through the squad.Spinner Mitchell Santner joined them in the sick bay on Thursday and while he was ruled out altogether yesterday, Williamson and Nicholls were allowed a net to test their fitness.“You could see pretty quickly that they weren’t right. Both those guys have been tough competitors and tough people,” said coach Gary Stead.“And when you don’t get an argument back around whether you should play or not, you know they are not very well.”The bug led to three changes to the team that lost heavily in Melbourne last weekend with batsman Glenn Phillips, who was flown over as cover on Thursday, handed his first cap.A fourth change was forced by the injury suffered by paceman Trent Boult in the second Test, but the fifth and last was the unexpected decision to drop experienced quick Tim Southee in favour of Matt Henry.“We just felt we wanted a bit more pace out there with what Matt offers over Tim,” Stead added.“The workload that Tim’s had, not just in the last two Tests, but you put the last four together it’s somewhere around about 200 overs in a short period of time. We felt that Matt would have given us a point of difference.”Southee and Henry could have both played, had New Zealand not elected to reduce their pace attack by one to make room for twin spinners Todd Astle and Will Sommervile on what they thought would be a dry wicket.That decision looked all the more questionable once stand-in captain Tom Latham had lost the toss.“We make decisions on what is in front of us and what are the best decisions to make at the time,” Stead said of the three-man selection panel. “We live and die by those as well.”
Jun 21 2018A groundbreaking discovery by University of Alberta researchers has identified previously-unknown therapeutic targets that could be key to preventing the spread of cancer.In a new study published in Nature Communications, the team found that by inhibiting several newly identified gene targets they could block more than 99.5 percent of cancer metastasis in living cells.”The potential significance is incredible,” said John Lewis, the Alberta Cancer Foundation Frank and Carla Sojonky Chair in Prostate Cancer Research at the U of A and a member of the Cancer Research Institute of Northern Alberta (CRINA). “Metastasis kills 90 percent of all patients with cancer. With this study we have discovered 11 new ways to potentially end metastasis.”In the study, the team used a unique platform it created–a shell-less avian embryo–to visualize the growth and spread of cancer cells in real time. The researchers used a molecular tool called a knockout library to insert short hairpin RNA (shRNA) vectors into cancer cells, which bound to specific genes in the cells and stopped them from activating. They then inserted those cancer cells into the embyros and observed as they formed clusters of cancer, identifying which ones showed properties of being non-metastatic.”When we found compact colonies [of cancer], that meant all the steps to metastasis were blocked,” said Konstantin Stoletov, lead author of the study and a research associate in the Lewis lab. “After that we could pull them out, query what the gene is, and then validate that the gene is actually responsible for metastasis.”The approach enabled the team to detect and identify 11 genes that appear to play essential roles in cancer cell metastasis. According to the researchers, these genes are widely involved in the process of metastasis and not unique to any one cancer.Related StoriesNew research links “broken heart syndrome” to cancerNew protein target for deadly ovarian cancerStudy reveals link between inflammatory diet and colorectal cancer riskThey now plan to test the metastasis-associated genes and gene products as drug targets with an aim of stopping metastasis.”We know that cancer, once it becomes metastatic, will continue to seed other parts of the body and the disease will progress and get worse because of that,” said Lewis. “So I think if we can stop metastasis at any step of progression in cancer patients, we’re going to have a significant effect on survival.”The team is now hoping to progress to human trials over the next few years. The Lewis lab is also expanding efforts to explore for other types of genes called microRNAs that may present even stronger therapeutic targets for preventing metastasis.The research was funded by the Canadian Cancer Society and the Alberta Cancer Foundation.”As the largest national charitable funder of cancer research, we are committed to funding the very best cancer research in Canada,” said Judy Bray, VP Research at the Canadian Cancer Society. “We are proud to have supported the work of Lewis and his team in developing this innovative new imaging tool and applying it to broaden our understanding of cancer metastasis. Discoveries like this will provide new leads on how we can block cancer from spreading and improve the outcomes of those affected by this disease.””Our donors have been proud to be supporting Dr. Lewis and his team for years and this is exactly the type of return on investment we like to see,” said George Andrews, President and CEO of the Alberta Cancer Foundation. “This groundbreaking research has a direct impact on improving treatment for patients and beyond and we are excited to see it translate into real outcomes for Albertans facing cancer.” Source:http://www.med.ualberta.ca/