George Groves will fight former world champion Glen Johnson at the ExCeL London on 15 December.The veteran Jamaican, 43, has been named as the surprise opponent for Groves’ defence of his Commonwealth super-middleweight title on the Frank Warren-promoted bill, which will be headlined by Scotland’s world lightweight champion Ricky Burns.Johnson won the IBF light-heavyweight title in 2004 and later that year pulled off a sensational victory by knocking out Roy Jones Jnr.His long list of opponents also includes Nottingham’s world champion Carl Froch, who won a close points decision when the pair met last year.Groves, unbeaten in his 15-fight professional career, expects the wily Johnson to provide his trickiest test so far.“It will be my toughest challenge – no-one has an easy fight against Glen Johnson,” said the 24-year-old.“I’m buzzing for the fight and am preparing for 12 hard rounds because he will give anyone a hard night’s work. I’ll be ready.”Groves, from Hammersmith, recently relinquished the British title after a planned September defence against mandatory challenger Kenny Anderson failed to materialise.An expected rematch with Anderson – who floored him before he battled back to win when they met in 2010 – was scrapped because of a cut Groves sustained in a bruising encounter with Francisco Sierra in California in July.Earlier this year Groves was forced to withdraw from a world title shot against German-based Russian Robert Stieglitz – then the WBO champion – because of injury.“It’s been a difficult year but I had a good win in America and now I’m going to have another good win in December,” he said.“It’ll be a tough challenge but I’m ready for it. I’ve felt ready for quite a while. I’m heading in the right direction for a world title.”See also:Bloodied Groves prevails in San Jose scrapGroves eyes fight at Stamford BridgeGroves’ Wembley fight is off because of cutGroves lines up December title defenceWatch the press conference to announce Groves’ clash with JohnsonGroves believes he can stop JohnsonFollow West London Sport on TwitterFind us on Facebook
Ten years after the Human Genome Project was completed, now we know: biology is “orders of magnitude” more complicated than scientists expected. So wrote Erika Check Hayden in Nature News March 31 and in the April 1 issue of Nature.1 An air of daunting complexity haunts the article. The Human Genome Project was one of the great scientific investigations of the end of the 20th century. Some compared it to the Manhattan Project or the Apollo program. It used to be tedious, painstaking work to read the sequence of DNA letters. Now, deciphering genomes is a matter of course. But with the rush of data coming from genomes of everything from yeast to Neanderthals, one thing has become clear: “as sequencing and other new technologies spew forth data, the complexity of biology has seemed to grow by orders of magnitude,” Hayden wrote. A few things were surprisingly simple. Geneticists expected to find 100,000 genes in the human genome; the count is more like 21,000. But with them came a huge surprise in the accessory molecules – transcription factors, small RNAs, regulators – all arranged in dynamic interacting networks that boggle the mind. Hayden compared them to the Mandelbrot set in fractal geometry that unveils deeper levels of complexity the closer you look. “When we started out, the idea was that signalling pathways were fairly simple and linear,” says Tony Pawson, a cell biologist at the University of Toronto in Ontario. “Now, we appreciate that the signalling information in cells is organized through networks of information rather than simple discrete pathways. It’s infinitely more complex.”Hayden acknowledged that the “junk DNA” paradigm has been blown to smithereens. “Just one decade of post-genome biology has exploded that view,” she said, speaking of the notion that gene regulation was a straightforward, linear process – genes coding for regulator proteins that control transcription. “Biology’s new glimpse at a universe of non-coding DNA – what used to be called ‘junk’ DNA – has been fascinating and befuddling.” If it’s junk, why would the human body decode 74% to 93% of it? The plethora of small RNAs produced by these non-coding regions, and how they interact with each other and with DNA, was completely unexpected when the project began. These realizations are dissipating some of the early na�vet� of the Human Genome Project. Planners predicted we would “unravel the mysteries behind everything from evolution to disease origins.” Cures for cancer were envisioned. We would trace the path of evolution through the genetic code. That was so 1990s. Joshua Plotkin, a mathematical biologist at the University of Pennsylvania in Philadelphia, said, “Just the sheer existence of these exotic regulators suggests that our understanding about the most basic things – such as how a cell turns on and off – is incredibly na�ve.” Leonid Kruglyak, a geneticist at Princeton University in New Jersey, commented on the premature feeling that the data would speak for itself: “There is a certain amount of naivety to the idea that for any process – be it biology or weather prediction or anything else – you can simply take very large amounts of data and run a data-mining program and understand what is going on in a generic way.” Some are still looking for simple patterns in the complexity. Top-down approaches try to build models where the data points fall into place:A new discipline – systems biology – was supposed to help scientists make sense of the complexity. The hope was that by cataloguing all the interactions in the p53 network, or in a cell, or between a group of cells, then plugging them into a computational model, biologists would glean insights about how biological systems behaved. In the heady post-genome years, systems biologists started a long list of projects built on this strategy, attempting to model pieces of biology such as the yeast cell, E. coli, the liver and even the ‘virtual human’. So far, all these attempts have run up against the same roadblock: there is no way to gather all the relevant data about each interaction included in the model.The p53 network she spoke of is a good example of unexpected complexity. Discovered in 1979, the p53 protein was first thought to be a cancer promoter, then a cancer suppressor. “Few proteins have been studied more than p53,” she said. “…Yet the p53 story has turned out to be immensely more complex than it seemed at first.” She gave some details:Researchers now know that p53 binds to thousands of sites in DNA, and some of these sites are thousands of base pairs away from any genes. It influences cell growth, death and structure and DNA repair. It also binds to numerous other proteins, which can modify its activity, and these protein�protein interactions can be tuned by the addition of chemical modifiers, such as phosphates and methyl groups. Through a process known as alternative splicing, p53 can take nine different forms, each of which has its own activities and chemical modifiers. Biologists are now realizing that p53 is also involved in processes beyond cancer, such as fertility and very early embryonic development. In fact, it seems wilfully [sic] ignorant to try to understand p53 on its own. Instead, biologists have shifted to studying the p53 network, as depicted in cartoons containing boxes, circles and arrows meant to symbolize its maze of interactions.Network theory is now a new paradigm that has replaced the one-way linear diagram of gene to RNA to protein. That used to be called the “Central Dogma” of genetics. Now, everything is seen to be dynamic, with promoters and blockers and interactomes, feedback loops, feed-forward processes, and “bafflingly complex signal-transduction pathways.” “The p53 story is just one example of how biologists’ understanding has been reshaped, thanks to genomic-era technologies,” Hayden said. “….That has expanded the universe of known protein interactions – and has dismantled old ideas about signalling ‘pathways’, in which proteins such as p53 would trigger a defined set of downstream consequences.” Biologists made a common mistake of assuming that more data would bring more understanding. Some continue to work from the bottom up, believing that there is an underlying simplicity that will come to light eventually. “It’s people who complicate things,” remarked one Berkeley researcher. But one scientist who predicted the yeast genome and its interactions would be solved by 2007 has had to put off his target date for a few decades. It’s clear that our understanding remains very rudimentary. Hayden said in conclusion, “the beautiful patterns of biology’s Mandelbrot-like intricacy show few signs of resolving.” There’s a bright side to the unfolding complexity. Mina Bissell, a cancer researcher at the Lawrence Berkeley National Laboratory in California, confesses she was “driven to despair by predictions that all the mysteries would be solved” by the Human Genome Project. “Famous people would get up and say, ‘We will understand everything after this’,” Hayden quoted her saying. But it turned out for good, in a way: “Biology is complex, and that is part of its beauty.”1. Erika Check Hayden, “Human genome at ten: Life is complicated,” Nature 464, 664-667 (April 1, 2010) | doi:10.1038/464664a.Who predicted the complexity: the Darwinians or the intelligent design proponents? You already know the answer. The Darwinians have been wrong on this matter time and time again. The origin of life would be simple (the Warm Little Pond of Darwin’s dreams). Protoplasm would be simple. Proteins would be simple. Genetics would be simple (remember Darwin’s pangenes?). The carrier of genetic information would be simple. DNA transcription would be simple (the Central Dogma). The origin of the genetic code would be simple (the RNA World, or Crick’s “frozen accident.”). Comparative genomics would be simple, and we would be able to trace the evolution of life in the genes. Life would be littered with the trash of mutations and natural selection (vestigial organs, junk DNA). Simple, simple, simple.Simple-minded.(Visited 52 times, 1 visits today)FacebookTwitterPinterestSave分享0
There are many ways to wear a doek, or duku – an African headwrap. In fact, South African entrepreneur Princess Ofentse Maluleke can show you up to 50 different, fashionable styles. She recently published a tutorial book, 50 Shades of Duku, after she realised many of her customers had trouble tying their doeks.“My friend and I sell headwraps at the market. Customers would say they would love to wear a headwrap but don’t know how to tie it,” she explains.“You get videos on YouTube on how to tie a headwrap, but when you have several minutes to get ready in the morning, you don’t have time to look up a website.”Princess Ofentse Maluleke, who sells her own shea butter and wrote a book on how to style an African headwrap, says she has been an entrepreneur all her life. (Image: Taji Shop, Shopify)The writing processIt prompted her to write a book about different styles. “At the time I started, I only had 30 styles. The other 20 I made up – I mixed styles and created new ones. It really pushed my mental boundaries.”Maluleke says she wanted to do a good number of styles. “I thought 20 was too little. I wanted a significant number, because I wanted it to be like a klap (punch). I felt 50 was enough, not too much to burn me out.”She started writing her book in April this year and finished it by the end of May. The electronic book version has been available on her website since 31 May. “My aim is to write at least 10 books in my lifetime about different things.”Her supportHer book is sold as an e-book, as a print book or as a combination book and headwrap. “I have had Canadians and American tourists saying that my combo was a great gift to take back home.”Maluleke, a business science degree graduate, says she is very excited about this project. “I feel like I am at the right place in my life.”Her family is proud of her achievements. “They are very supportive. My brother, for instance, funded my first batch of books. My mom, Sally Tsipe, is distributing the books in KwaZulu-Natal and my sister, Omolemo Tsipe, distributes them in Cape Town.”Her husband and a friend helped her to finish the book.Part-time entrepreneurAs the chief executive officer of the Taji Shop, Maluleke says she has been a part-time entrepreneur all her life. “In high school I was known as the ‘Popcorn Lady’ and in university I would redesign old clothes to sell. I taught myself to sew. I started as a full-time entrepreneur earlier this year.”It began with selling her own organic shea butter body cream. “I get the shea butter raw from Ghana and add different oils to make the product easier to use. You can use it for your skin and hair.”Her duku partiesMaluleke, who lives in Johannesburg, is often invited to women’s parties such as baby showers to teach her duku styles. “I do one-on-ones and small groups. Showing a couple of duku styles is a great educational element at women’s events.”In many African cultures, a young bride wears a duku as a sign of respect, because they cover their heads, she explains. “I am also a young bride.”But you don’t have to be a young bride to wear a duku. “Also, you can make it look fashionable.”There are also no-nos: In an interview on radio station Power FM 987, Maluleke warned that wearing a headwrap tied too tightly could cause a “scarf headache”. Also, matching a doek to your outfit could be done wrong. “Rather stick to neutrals and go wild on yourdoek.”Another tip is to use an under-scarf – some fabric or another headwrap – to add volume to your doek.Maluleke also hosts her own duku parties where her doek combos are sold, and she teaches her audience how to use a T- shirt instead of a headwrap to create a doek style.Next up, she plans to take her parties all over South Africa.Would you like to use this article in your publication or on your website?See Using SouthAfrica.info material
Facebook is Becoming Less Personal and More Pro… The Dos and Don’ts of Brand Awareness Videos Tags:#Facebook#NYT#web A Comprehensive Guide to a Content Audit Related Posts This morning, Facebook released its much-feared commenting solution. The idea made big news earlier this year, despite the fact that Facebook has already offered a commenting solution for more than a year, but today the company has announced the feature officially. So what’s new? There are a number of features for both publishers and users, although some of the most exciting features we’ve seen displayed on Facebook late last year don’t appear to be a part of the release. Is Facebook’s massive social graph enough to push it into the default slot for comments, where it already resides for things like social sharing and third-party login?According to a Facebook spokesperson, the new commenting system will be a quick install for publishers, with a single line of code. Sharing comments on Facebook will, of course, be seamless. This is probably the biggest impetus to use the system – comments made on the publisher’s site or on Facebook itself will be displayed in both locations. The new commenting feature will also come with moderation controls so administrators can blacklist certain users and language.On the user end, there’s the obvious benefit of serving as a quickly and easily accessible commenting system. That is, if you want to comment using your Facebook identity. All users commenting will have to be logged in using Facebook, which could present a problem for some who either don’t want to link their real identity with their commenting or who don’t have a Facebook account. Now, more information than ever could be available on third-party sites using the Facebook comment plugin:You can obtain more context about a person by looking at the text next to their name, which will show if you have a mutual friend, the person’s work title, the person’s age, or the place that a person currently lives. This information will always respect the person’s privacy settings and will only show what you can already see on Facebook.Beyond that, most features are as expected – comments are threaded, will rise or drop according to the number of likes they receive, users can help mark comments as spam or abusive and share comments back to Facebook. The feature some will be most excited about, we expect, is the ability to comment as a Facebook Page, rather than just a user. The big question is, where are all the bells and whistles? Remember this?We got a glimpse of this commenting system on Facebook back in October 2010 and it looked like something to really be excited about. It had comment voting, rating counts, and gave individual stats on each commenter and comment. It looks like some of those features have been pulled into the background, as we’re still seeing user networks in the new system, but no more down-voting. What’s a user got to do to get a dislike around here?The feature is launching with four initial partners: Discovery.com, Examiner.com, Sporting News and SBNation.Will this be the feature to put companies like Disqus and Livefyre out of business? Facebook’s 600-plus million strong network is a strong argument as it allows what we imagine to be a simple and easy implementation. The only thing that gives us pause is the continued resistance we’ve seen from users to adopt the idea that they visibly use their Facebook identity – their real, linked name – in other places on the Web. Most other commenting systems offer a variety of options, while Facebook will offer just one – Facebook.Unless, of course, Peter Kafka was correct, but we haven’t seen that functionality mentioned or in use quite yet. According to TechCrunch, the new commenting system will only allow one other identity: Yahoo. Apparently Facebook is working with other parties, but we have yet to see two big players get in the game yet: Twitter and Google. Can these companies work together on this one? Will Facebook be willing to give up control over the one thing it has sought domination over – your online identity? Guide to Performing Bulk Email Verification mike melanson
Fannie Mae, the largest provider of financing for multifamily projects in the country, says that it has started giving loan discounts on properties with a green-building certification. The announcement came from the U.S. Green Building Council, which administers the well-known LEED program. But the loan break also applies to projects that qualify for Energy Star status as well as those certified under the Enterprise Green Communities Criteria.The discount equals 10 basis points, or one-tenth of 1 percent on the loan. In the example USGBC cited, a 4 percent market rate loan would drop to 3.9 percent. If that sounds like small potatoes, interest savings on a $10 million loan amortizing over 30 years would be $95,000 over a 10-year period, according to the USGBC.Jeffery Hayward, executive vice president for multifamily with Fannie Mae, said that green certification offers three advantages: lower operating costs for owners and tenants, the social benefits of providing quality housing for renters, and environmental benefits that help everyone.Fannie Mae has more details about its ongoing Green Initiative at its website.
The makers of the upcoming James Bond film Bond 24 are reportedly in search of new iconic character like Jaws or Oddjob to feature in the movie.Filming for the Sam Mendes directed project would begin December 2014 According to James Bond’s fan-site MI6, the producers were considering former sports athletes who were extremely physically fit and over 6’2 for the part of their main assassin in the Daniel Craig starrer project, Metro.co.uk reported.The website added that the character, which has been temporarily named ‘Hinx’ and believed to be between 30- 45 years of age, would have altercation scenes with Craig in addition to a driving sequence.It was also reported that filming for the Sam Mendes directed project would begin December 2014.